• Users Online: 66
  • Print this page
  • Email this page
REVIEW
Year : 2017  |  Volume : 4  |  Issue : 1  |  Page : 28-48

Therapy induced senescence and its implications in cancer


Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai – 410210; Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai – 400085, India

Correspondence Address:
Shilpee Dutt
Shilpee Dutt Laboratory, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai – 410210
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2349-3666.240590

Rights and Permissions

Senescence is a phenomenon of ‘end of cells replicative capacity’, characterized by irreversible cell cycle arrest which in the context of cancer, will contain the growth of tumour. Hence possibility of using pro-senescence therapies for cancer therapeutics has generated substantial interest. In this regards there are several reports showing that senescence can be induced in cancer cells by genotoxic agents used in anti-neoplastic therapy, such senescence is called ‘therapy induced senescence’ (TIS). Therapy induced senescent cells undergo cell death or eventual immune-mediated clearance. However, recent reports also show the existence of ‘therapy induced senescence reversal’ mechanisms in some cancers, wherein after a definite period of time, senescent cells overcome the arrest and re-enter the cell cycle, eventually repopulating the tumour which will limit the use of senescence for cancer therapeutics. The data also highlighs that TIS is complex and we do not fully understand many aspects of this phenomenon. Therefore to harness senescence for cancer therapeutics, a deeper understanding of the underlying molecular mechanisms governing establishment and reversal of senescence is required. In the current review, we have discussed current knowledge of the therapeutic agents inducing senescence, their mechanism of induction and the implication of senescence reversal in cancers.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed228    
    Printed40    
    Emailed0    
    PDF Downloaded53    
    Comments [Add]    

Recommend this journal