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REVIEW ARTICLE
Year : 2019  |  Volume : 6  |  Issue : 1  |  Page : 1-6

Klotho: An emerging factor in neurodegenerative diseases


Department of Biochemistry, Sir H. N. Medical Research Society, Mumbai, Maharashtra, India

Correspondence Address:
Ms. Gauri V Pathare
Sir H. N. Medical Research Society, Court House, L. T. Road, Mumbai - 400 002, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/BMRJ.BMRJ_3_19

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Soluble Klotho protein is present in blood, urine, and cerebrospinal fluid and works as a humoral factor exerting different biological effects. Several animal studies have demonstrated the association of age-related neurodegeneration with Klotho deficiency. Lower Klotho levels have been reported in patients suffering from cognitive impairment, dementia, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and other neurodegenerative diseases. Due to its antiaging properties, Klotho is the obvious choice to be studied as a protective/therapeutic agent in neurobiology. In this review, we have attempted to shed light on the different neurodegenerative diseases affected by deficiency of Klotho and its neuroprotective role against pathogenicity of the disease.


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