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  Indian J Med Microbiol
 

Figure 1: Pathways showing mechanism of action of cyclooxygenases, acid-sensing ion channel-1a, matrix metalloproteinase-2, and matrix metalloproteinase-9 initiating the neuronal death. ( a) Interrelation of free radicals, acid-sensing ion channel-1a, and matrix metalloproteinases, (b) cyclooxygenase activation and its effects, (c) abnormal opening of acid-sensing ion channel-1a and its effects

Figure 1: Pathways showing mechanism of action of cyclooxygenases, acid-sensing ion channel-1a, matrix metalloproteinase-2, and matrix metalloproteinase-9 initiating the neuronal death. <b>(</b> a) Interrelation of free radicals, acid-sensing ion channel-1a, and matrix metalloproteinases, (b) cyclooxygenase activation and its effects, (c) abnormal opening of acid-sensing ion channel-1a and its effects