Figure 1: Functional association of genes containing the single-nucleotide polymorphisms in apoptosis, proliferation and angiogenesis of cancer cells. Spleen tyrosine kinase enhances apoptosis through PKC, interleukin-1 receptor-associated kinase leads to apoptosis through IKK and TGFBR2 has a dual role in cancer by activating apoptosis and proliferation. Endothelin binds to its receptor Endothelin Receptor Type A and activates proliferation and angiogenesis and PTP binds its receptor PTPR to inhibit proliferation